一群医学院实习医生某晚在医院附近酒吧玩乐时捉弄具有偷窥癖的医院清洁工肯尼斯（安德鲁-李•波茨 Andrew-Lee Potts 饰），并戏虐他为“疯狗”。被逼饮酒过量的肯尼斯癫痫发作昏厥，成为植物人，

一个堕落的综合格斗女拳王无意中来到一个类似阴曹地府的未知空间，在那里她必须赢得多场不受限制的死亡比武，她的对手既有人类也有各种野兽甚至恶魔，最终她能否拯救自己的灵魂涅槃重生？

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